Ampoule / Vile Machines

Used Ampoule / Vile Equipment

Ampoule filler machines are typically used in the pharmaceutical industries to fill a range of liquids with viscosities from free-flowing to heavy oils.  There are many types of containers that can be filled including; ampoules / ampoules, vials, glass tubes, onion skin tubes, and many others.

Ampoule and Vile fillers typically unscramble, gas flush, and fill the container.  The ampoules are then hermetically flame sealed, or vials are plugged and capped depending on the application.

Glass ampules (Sometimes “ampoules”) are the ultimate tamper evident/resistant package. Popular for injectable pharmaceutical products, they are also used for other speciality products like cosmetics. Ampules are available in sizes from a few milliliters to a few ounces.  More: Watch Ampoule Filler Video

ampoule-filler

Before Sealing After Sealing

The ampule is formed from glass tubing and consists of a body, where the product will normally be, a neck that is designed to break and an upper section that is flame sealed. The ampules are typically supplied in shrinkwrap film. In most pharma applications, the shrinkwrapped film is removed and the ampules are washed and sterilized. Transport trays are used to transfer the ampules to the filler infeed. There they are placed on a rotary or inline infeed that single files them into the filler. A pusher block, on the table or conveyor, is usually used to prevent the ampules from falling over backwards.

Another alternative is to use an inclined infeed tray to the filler. Ampules are loaded on the tray and gravity prevents them falling. Gravity also drives them to the filler.
At the table or tray discharge, the ampules are single filed into the filler where they are captured in pockets in a trunnion chain or a walking beam.

trunnion-chain

Trunnion chain

These move the ampule into the filling section. Filling needles are lowered into the lower chamber of the ampule and the product is dispensed. Filling can be with piston, peristaltic, gear or other pump or by time-pressure. It is critical that no splashing or dripping occur in the upper portion of the ampule. If there is any product in the upper chamber, it will be burned during sealing, ruining the product.

After filling, the ampule is indexed to the sealing section. Gas flames heat the ampule below the tip. A pair of metal fingers grip the tip pulling it upward. As the tip and ampule are pulled apart, the molten glass seals closed. The fingers deposit the scrap in a waste chute. This picture shows ampules indexing, two up, to a preheating and final sealing station.

ampoule filler flame sealer

Preheating and sealing stations (2 up)

The sealed ampule exits the filler and is collected in a tray or accumulation table or conveyed for labeling and packing.
At point of use, the sealed tip is snapped off. This leaves the body open at the neck. Since it is broken open, it cannot be resealed. This makes them an excellent one time use package.

Frain Industries carries used ampoule / vial liquid fillers from many manufacturers including Bosch, Cozzoli, Marzocchi, and many others.

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Ampoule / Vile Equipment In Stock

Cozzoli Filler Liquid Ampule FPS2-FFF

  • Manufacturer: Cozzoli
  • Model Number: FPS2-FFF
  • Frain Number: 5H4160

Cozzoli Model FPS2, automatic, intermittent motion, 2 head flush, fill, flush and flame sealer with number of containers per minute – depending on materials, application and machine configuration. Fill range: 1cc to 30cc with accuracies +/- 0.5%. Container size range: 3/8" to 1" in Diameter; up to 5-5/16" in Height (change parts required to accommodate different size and fill ranges). Equipped with 24" OD disc unscrambling table with feed shoe and 24" long container roller conveyor, with centering posts, no container / no fill and 2 heads, flush, fill, flush with 4 head flame sealing station and dual picker arms reject chute, gas hoses, pressure gauges, with start and stop switches. Mounted on base frame.

OAD: 48" L x 24" W x 44" H

Get a Free Quote Call: 630-629-9900

Cozzoli Filler Liquid Ampule FPS4

  • Manufacturer: Cozzoli
  • Model Number: FPS4
  • Frain Number: 5B8033

Fully automatic 4 head ampul filler/flame sealer. Ampul fill size range 1- 30 cc. Currently set with 5 cc pistons. Container range: 9 – 25 mm (3/8" – 1") dia , height to 120 mm (4 3/4"). Is flush/fll/flush operation. Complete w/24" dia rotary unscrambling table & infeed that reduces ampuls to close order single file. Has no ampul/no fill feature. Speed dependant on materials and application. Change parts may be required to accommodate size & fill range.

Get a Free Quote Call: 630-629-9900

Cozzoli Filler Liquid Ampule FPS4

  • Manufacturer: Cozzoli
  • Model Number: FPS4
  • Frain Number: 5F4250

Automatic, intermittent motion, 4 head flush, fill, flush and flame sealer. Fill range: 1ml to 30ml Container size range: 3/8" to 1" in Diameter; up to 4-3/4"" in Height. Equipped with 24" feed table, conveying system, no container / no fill, flush, fill, flush with flame sealing station. All stainless steel contact parts. Speed dependant on materials and application. Change parts may be required to accommodate size & fill range.

OAD: 64" L x 24" W x 48" H

Get a Free Quote Call: 630-629-9900

Cozzoli Filler Liquid Ampule FPS1

  • Manufacturer: Cozzoli
  • Model Number: FPS1
  • Frain Number: 5G0900

Cozzoli Model FPS1, automatic ampule filler flame sealer. Container size range: 3/8" (9.5mm) to 1" (25.4mm) in Diameter; 5-5/16" (134.9mm) maximum height. Equipped with rotary unscrambler, 1 filling head, peristaltic pump with range of 1cc – 30cc, gas flush, and flame seal with height range 1-3/4" (44mm), to 4-3/4" (120mm). Unit intermittently unscrambles, fills, flushes, and flame seals ampules. Discharge height of 32". Speed dependant on materials, application and machine configuration. Change parts may be required to accommodate size & fill range.

OAD: 52" L x 26" W x 48" H

Get a Free Quote Call: 630-629-9900

Cozzoli Filler Liquid Ampule FPS2

  • Manufacturer: Cozzoli
  • Model Number: FPS2
  • Frain Number: 5F4515

Cozzoli Model FPS2, automatic, intermittent motion, 2 head flush, fill, flush and flame sealer. Fill range: 1cc to 30cc Container size range: 3/8" to 1" in Diameter; up to 5-5/16" in Height. Equipped with 24" feed table, 24" roller conveying system, centering posts, no container / no fill, flush, fill, flush with 4 head flame sealing station, reject chute and receiving tray. All stainless steel contact parts, gas hoses and pressure gauges, safety guarding with start / stop switch. Speed dependant on materials, application and machine configuration. Change parts may be required to accommodate size & fill range.

OAD: 48" L x 44" W x 46" H

Get a Free Quote Call: 630-629-9900

Cozzoli Filler Liquid Ampule FPS4

  • Manufacturer: Cozzoli
  • Model Number: FPS4
  • Frain Number: 5B8034

Fully automatic 4 head ampul filler/flame sealer. Ampul fill size range 1- 30 cc. Currently set with 5 cc pistons. Additional size pistons available, one set included with machine. Container range: 9 – 25 mm (3/8" – 1") dia , height to 120 mm (4 3/4"). Is flush/fll/flush operation. Complete w/24" dia rotary unscrambling table & infeed that reduces ampuls to close order single file. Has no ampul/no fill feature. Was last used in pharmaceutical operation.

Get a Free Quote Call: 630-629-9900

Cozzoli Filler Liquid Ampule FS250

  • Manufacturer: Cozzoli
  • Model Number: FS250
  • Frain Number: 5B5081

Stainless steel inline filler rated to 60 cpm with a fill range from 2ml to 60ml. Container size range: 5/8" to 1-1/4" diameter; to 7" tall.

OAD: 48" L x 27" W x 54" H

Get a Free Quote Call: 630-629-9900

Bosch Pharma Filler Liquid Ampule ALK3040 filling machines

  • Manufacturer: Bosch Pharma
  • Model Number: ALK3040
  • Frain Number: 5D1291

4 head ampule filler sealer capable of filling at speeds of 100 to 400/minute. Equipped with a slant tray infeed to a worm screw, automatic star wheel feeding ampules into 4 up indexing conveyor, 4 head air cleaner, 4 filling pistons, 4 head sealing station, to a automatic trayer. Capable of filling 1,2,5 & 10ml (with proper change parts). Last running in a pharmaceutical operation filling a saline solution in 2ml ampules at 225/min. Currently set for ampules, stoppering station can be added to system to run vials.

OAD: 124"L x 70"W x 54"H

Get a Free Quote Call: 630-629-9900

Cozzoli Filler Liquid Ampule FS250

  • Manufacturer: Cozzoli
  • Model Number: FS250
  • Frain Number: 5F9821

Cozzoli Model FS250, automatic, intermittent motion ampule flush / fill / flush / flame sealer rated from 2 to 60 containers per minute – depending on materials and application. All stainless steel product contact parts. Fill range: 2ml to 60ml with + / – 0.5% accuracies. Container size range: 5/8" to 1-1/4" in Diameter; to 7" in Height. Sealing height: 2-1/2" to 6-5/8". Equipped with 24" OD feed table, 20" long roller conveying system, centering posts, with no container / no fill, flush, fill, seal, with 2 filling and 4 flame sealing stations with dual pick off arms and reject chute with safety guarding. Control panel has vari speed drive and machine on / off switch and start / e-stop buttons. Mounted on stainless steel base frame.

OAD: 72" L x 42" W x 56" H

Get a Free Quote Call: 630-629-9900

Cozzoli Filler Liquid Ampule FS250

  • Manufacturer: Cozzoli
  • Model Number: FS250
  • Frain Number: 5F9820

Cozzoli Model FS250, automatic, intermittent motion ampule flush / fill / flush / flame sealer rated from 2 to 60 containers per minute – depending on materials and application. All stainless steel product contact parts. Fill range: 2ml to 60ml with + / – 0.5% accuracies. Container size range: 5/8" to 1-1/4" in Diameter; to 7" in Height. Sealing height: 2-1/2" to 6-5/8". Equipped with 24" OD feed table, 20" long roller conveying system, centering posts, with no container / no fill, flush, fill, seal, with 2 filling and 4 flame sealing stations with dual pick off arms and reject chute with safety guarding. Control panel has vari speed drive and machine on / off switch and start / e-stop buttons. Mounted on stainless steel base frame.

OAD: 72" L x 42" W x 56" H

Get a Free Quote Call: 630-629-9900